کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3475316 1233190 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of anticonvulsant activity of hydroalcoholic extract of Mussaenda philippica on animals
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Evaluation of anticonvulsant activity of hydroalcoholic extract of Mussaenda philippica on animals
چکیده انگلیسی

ObjectiveTo evaluate the anticonvulsant activity of hydroalcoholic extracts of leaves and sepals of Mussaenda philippica (M. Philippica) and its fractions (methanol, dioxin and aqueous) against pentylene tetrazole (PTZ), maximal electroshock (MES), Strychnine (STR), Picrotoxin induced convulsions at different dose levels.MethodsThe anticonvulsant effect of extracts was studied by the MES, PTZ, STR and Picrotoxin-induced seizure.ResultsThe extract at 100 and 200 mg/kg, produced a significant (P <0.01) dose dependent increase in onset of convulsion compared to the control in MES, PTZ, strychnine and picrotoxin-induced seizures.ConclustionsThe data obtained indicates that Hydroalcoholic extracts of M. philippica leaves and sepals may help to control grandmal and petitmal epilepsy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Acute Disease - Volume 3, Issue 1, 2014, Pages 46-50