Antiulcer activity of aqueous extract of leaves of Madhuca indica J. F. Gmel against naproxen induced gastric mucosal injury in rats

ObjectiveTo evaluate antiulcer potential of aqueous extract of Madhuca indica (M. indica) J. F. Gmel leaves in rats.MethodsAqueous extract of M. indica J.F. Gmel leaves was tested at the dose of 100, 200 and 400 mg/kg, p.o. against naproxen (30 mg/kg, p.o) induced gastric ulcer. Omeprazole (30 mg kg, p.o.) was used as a positive standard. Ulcerated area was measured by Image J software. Various antioxidant parameter like SOD, GSH, MDA, MPO, NO and histamine were also determined.ResultsAfter 4 week treatment period, desired aim was achieved using aqueous extract of plant of M. indica at the dose of 200 and 400 mg/kg, p.o. (P<0.01, P<0.001) showed significant reduction in ulcerated area and ulcer index as compared to control group. Omeprazole (30 mg/kg, p.o.) was more effective in reducing ulcerated area after 30 days treatment period. In addition, SOD, GSH, NO significantly increased; MDA, MPO content significantly lowered when compared with control group. Histamine content didn't show any significant change at all the three doses.ConclusionsOur finding suggests that aqueous extract of M. indica J.F. Gmel leaves is effective in gastric ulcer protection.