کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3476709 | 1233276 | 2011 | 5 صفحه PDF | دانلود رایگان |
BackgroundWe aimed to establish a feasible and reliable method to measure the level of aripiprazole and its main metabolite, dehydroaripiprazole, using a capillary-electrophoresis (CE) machine.MethodsTwo blood samples were obtained from psychiatric patients hospitalized in Yu-Li Hospital who had been treated with aripiprazole for more than 4 weeks, at least 10 mg/d. Conditions for voltage, temperature and buffer concentration was optimized on a CE machine.ResultsThe most optimal conditions for CE were 80 mM 2–3% DMSO-phosphate as a buffer under pH = 3.0, 15 KV, 20°C and a detection wavelength of 214 nm. The linear ranges of aripiprazole and dehydroaripiprazole concentration were from 0.5 to 50 ng/mL.ConclusionCE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.
Journal: Journal of the Chinese Medical Association - Volume 74, Issue 6, June 2011, Pages 267–271