کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3477273 1233314 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neoadjuvant Concurrent Chemoradiotherapy in Treating Locally Advanced Rectal Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Neoadjuvant Concurrent Chemoradiotherapy in Treating Locally Advanced Rectal Cancer
چکیده انگلیسی

BackgroundColorectal cancer is a common cancer and a major cause of morbidity and mortality worldwide. Middle to lower rectal cancer, a challenge for surgeons, is problematic. Neoadjuvant concurrent chemoradiotherapy (CCRT), introduced in the last decade, leads the local control of advanced rectal cancer to a high percentage of R0 resection (margin negative under microscopic examination) and a low recurrence rate.MethodsFrom January 2005 to June 2007, 46 patients with locally advanced rectal cancer who received neoadjuvant CCRT were included. Factors including disease-free survival time, overall survival time, local recurrence, metastasis, and postoperative complications were evaluated retrospectively. Response was defined according to Mandard's classification, in which TRG1 is no residual tumor and TRG2–3 is 50–100% tumor shrinkage.ResultsIn this series, 3 patients who did not receive post-CCRT curative resection were excluded. The remaining 43 patients (22 males, 21 females) had received curative surgery and were included. Thirty-four patients had tumor shrinkage, and the response rate was 79% (Mandard's classification: TRG1–TRG3). The median follow-up time was longer than 1.5 years. Patients who responded to CCRT had lower local recurrence rates (5.9% vs. 55.6%; p = 0.002) and a greater curative resection rate (97.1% vs. 66.7%; p = 0.024). The complication rates of both groups were similar.ConclusionNeoadjuvant CCRT gives locally advanced rectal cancer patients a more favorable result, with acceptable toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Chinese Medical Association - Volume 72, Issue 4, April 2009, Pages 179-182