کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3477413 1233325 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Intra-articular Injection of Hyaluronic Acid in Rheumatoid Arthritis Patients with Knee Osteoarthritis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Effect of Intra-articular Injection of Hyaluronic Acid in Rheumatoid Arthritis Patients with Knee Osteoarthritis
چکیده انگلیسی

BackgroundIntra-articular injection of hyaluronic acid (HA) is a well-documented treatment for knee osteoarthritis (OA). One of the multifactorial mechanisms is that exogenous HA can stimulate endogenous HA production. HA can regulate the growth and function of chondrocytes by binding to CD44 receptors on the chondrocytes. Synovitis is often found in patients with rheumatoid arthritis (RA) and is supposed to result from CD44 activity. The aim of this study was to inves-tigate the effect of intra-articular injection of HA in patients with RA combined with knee OA.MethodsTwenty RA patients with OA knees were enrolled; 11 patients were placed into a stage II group and 9 into a stage III group, in accordance with the Kellgren-Lawrence classification of knee OA. All patients received intra-articular injection of HA (ARTZ) once a week for 5 weeks, and were evaluated with the WOMAC index (including the pain, stiffness and physical function subscales) at baseline, week 5 and week 9. The Friedman test and Wilcoxon signed rank test with Bonferroni correction method were used for statistical analysis.ResultsThe effect of intra-articular injection of HA was significant at week 5 (p <0.0167) and persisted to week 9 (p <0.0167). This therapy was equally efficacious with stage II and stage III patients, with no difference between the 2 groups.ConclusionIntra-articular injection of HA was beneficial in patients with RA combined with knee OA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Chinese Medical Association - Volume 71, Issue 8, August 2008, Pages 411-415