کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3478541 1233404 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evident cognitive impairments in seemingly recovered patients after midazolam-based light sedation during diagnostic endoscopy
ترجمه فارسی عنوان
اختلالات شناختی آشکار در بیماران به ظاهر بهبود یافته پس از آرامسازی نور مبتنی بر میدازولام در طی آندوسکوپی تشخیصی
کلمات کلیدی
عملکرد شناختی، آندوسکوپی، میدازولام، تغییر شاخص قابل اعتماد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

Background/PurposeMidazolam is a widely used sedative agent during colonoscopy, with cognitive toxicity. However, the potential cognitive hazard of midazolam-based light sedation has not been sufficiently examined. We aimed to examine the cognitive safety and vulnerability profile under midazolam light sedation, with a particular focus on individual variations.MethodsWe conducted a prospective case-controlled study in an academic hospital. In total, 30 patients undergoing sedative colonoscopy as part of a health check-up were recruited. Neuropsychological testing on the full cognitive spectrum was evaluated at 15 minutes and 120 minutes after low-dose midazolam administration. The modified reliable change index (RCI) was used for intrapersonal comparisons and controlling for practice effects.ResultsMidazolam affected psychomotor speed (48%), memory (40%), learning (32%), working memory (17%), and sustained attention (11%), while sparing orientation and the fluency aspect of executive function at the acute stage. Residual memory (10%) and learning (10%) impairments at 2 hours after administration were evidenced in some patients. The three object recall and digit symbol coding tests can serve as useful screening tools.ConclusionMidazolam-based light sedation induced selective cognitive impairments and prolonged cognitive impairments occurred in patients with advanced age. A longer observation time and further screening were recommended for patients due to their at risk state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Formosan Medical Association - Volume 114, Issue 6, June 2015, Pages 489–497
نویسندگان
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