کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3479088 | 1233432 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hepatitis B viral factors and treatment responses in chronic hepatitis B Hepatitis B viral factors and treatment responses in chronic hepatitis B](/preview/png/3479088.png)
Baseline and on-treatment hepatitis B viral factors are reported to affect treatment responses. A lower baseline hepatitis B virus (HBV) DNA level is a strong predictor of the response to antiviral therapy. HBV genotype A/B patients have better responses to interferon-based therapy than those with genotypes C/D. Regarding the association of HBV mutants with responses to antiviral therapy, current evidence is limited. On-treatment viral suppression is the most important predictor of response to nucleoside analogs. On-treatment hepatitis B surface antigen decline is significantly associated with response to pegylated interferon. In the future, individualized therapy should be based on treatment efficacy, adverse effects, baseline and on-treatment predictors of antiviral therapy.
Journal: Journal of the Formosan Medical Association - Volume 112, Issue 6, June 2013, Pages 302–311