کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3479383 1233449 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CD4+FoxP3+ regulatory T-cells in human systemic lupus erythematosus
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
CD4+FoxP3+ regulatory T-cells in human systemic lupus erythematosus
چکیده انگلیسی

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of immune tolerance to self antigens and by the persistent production of pathogenic autoantibodies. Recent studies have suggested a dysregulation of regulatory T-cells (Tregs), particularly CD4+CD25highFoxP3+ (forkhead box P3) Tregs, as one of the major factors conferring the risk for expression of human autoimmune diseases, including SLE. However, detailed studies of CD4+FoxP3+ T-cells in patients with SLE remain limited. We attempt here to integrate the current experimental evidence to delineate the role of CD4+CD25high and other subsets of CD4+FoxP3+ T-cells in human SLE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Formosan Medical Association - Volume 111, Issue 9, September 2012, Pages 465–470
نویسندگان
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