کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3481045 1233504 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of Human Cytomegalovirus in Atherosclerotic Carotid Arteries in Humans
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Detection of Human Cytomegalovirus in Atherosclerotic Carotid Arteries in Humans
چکیده انگلیسی

Background/PurposeAtherosclerosis plays an important role in stroke. A microbiological infection has been suggested to be involved in the pathogenesis of atherosclerosis, in particular the human cytomegalovirus (HCMV). The objective of this study was to determine the association between HCMV infection and atherosclerosis of the internal carotid arteries in patients of Chinese Han ethnicity with ischemic stroke.MethodsHCMV DNA and antigen were detected in atherosclerotic internal carotid arteries from 35 patients with ischemic stroke and 20 controls from a Chinese Han ethnic population. Immunohisto-chemistry, in situ hybridization and polymerase chain reaction were used to detect the HCMV immediate early (IE) and late (L) antigen as well as DNA in the vascular walls.ResultsWe observed that the proportion of cases that tested positive for HCMV IE but not L antigen and DNA was statistically greater in stroke patients compared with the control population.ConclusionHCMV IE antigen and DNA were associated with the pathological process of atherosclerosis. The vessel wall might be the infection site of the dormant virus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Formosan Medical Association - Volume 107, Issue 10, October 2008, Pages 774-781