Gastrointestinal migrating motor complex during early stage of cholesterol gallstone formation in guinea pigs

ObjectiveTo determine the changes of gastrointestinal migrating motor complex (MMC) during the early stage of cholesterol gallstone formation.MethodsTotally 45 healthy adult guinea pigs were randomly and equally divided into 3 groups, that is, normal control, group B (1% cholesterol diet for 2 weeks) and group C (1% cholesterol diet for 4 weeks). Three pairs of silver electrodes were inserted into the gastric antrum, duodenum and jejunum of every animal respectively. Record of gastrointestinal MMC of these guinea pigs were recorded and analyzed. Gallbladder bile was taken to detect the formation of cholesterol gallstone.ResultsThere were only 29 guinea pigs living. The MMC cycle time and the duration of phase II were prolonged significantly and gradually compared with the control group (P < 0.01), but the duration of phase III became significantly and gradually shorter.ConclusionDuring the early stage of cholesterol gallstone formation, the MMC cycle time and the duration of phase II are prolonged and the duration of phase III is shortened