کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3483048 1233693 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simple and accessible screening method for congenital thrombopathies using an impedance haematology counter
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
A simple and accessible screening method for congenital thrombopathies using an impedance haematology counter
چکیده انگلیسی

Glanzmann thrombasthenia (GT) and Bernard–Soulier syndrome (BSS) are hereditary autosomal recessive disorders of platelet functions. These two congenital thrombopathies are very rare. This rarity might be due to the misdiagnosis of the disease and the lack of reliable screening methods. Usually, the definitive diagnosis of these congenital defects relies on aggregometric, flow cytometric and molecular assays. Unfortunately, these expensive diagnostic tools are not always available in routine laboratories, especially in developing countries, leading to misdiagnosis and underestimation of the prevalence of these defects. In this paper, the authors suggest a simple and accessible screening method for detection of congenital thrombopathies using only a haematology counter and some reagents.

Figure optionsDownload as PowerPoint slideHighlights▸ An automated platelet count is underestimated each time aggregates are present in the sample. ▸ Adjunction of platelet agonist to a normal sample lead to formation aggregates. ▸ A drop of platelet count is observed after formation of aggregates. ▸ In case of thrombopathy, aggregates can not be formed and then the platelet count remains the same.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Medical Hypotheses and Ideas - Volume 7, Issue 1, January 2013, Pages 11–14
نویسندگان
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