کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3484123 1233730 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect and mechanism of homocysteine on Parkinson's disease induced by 6-OHDA
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Effect and mechanism of homocysteine on Parkinson's disease induced by 6-OHDA
چکیده انگلیسی

ObjectiveTo study the effects and mechanism of homocysteine(Hcy) on Parkinson'sdisease(PD) induced by 6-hydroxydopamine (6-OHDA) in vivo.MethodsForty rats were divided into 4 groups. 6-OHDA or the solvent of 6-OHDA was focally administrated to induce PD, 2 h later Hcy or 0.9% sodium chloride was administrated in the ipsolateral substantial nigra(SN). We used behavioral testing, Immolunohistochemical techniques, biochemistry techniques to detect the injury of SN.ResultsThe rotary turns of PD rats induced by 6-OHDA showed significant increase after treatment with Hcy compared with the controls(P < 0.05). Also the numbers of tyrosine hydroxylase(TH)-stained neurons were decreased, and dendrites were fragmented and truncated. Free radicals were increased and antioxidant enzymes decreased.ConclusionFocal infusion of Hcy into the SN increased the vulnerability of the dopaminergic neurons to 6-OHDA-induced degeneration, it seems that the endangering effect of Hcy is due to exacerbating oxidative stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Nanjing Medical University - Volume 22, Issue 1, January 2008, Pages 12-17