Effects of IL-4 on cyclooxygenase-2 and platelet-derived growth factor in the lungs of COPD rats

ObjectiveTo explore the role of interleukin 4 (IL-4), expressions of cyclooxygenase-2 (COX-2) and platelet-derived growth factor (PDGF) in the model of chronic obstructive pulmonary disease (COPD), in the lungs of rats.MethodsMale Wistar rats were used to build up the model of COPD. Rats were randomly divided into the control group and model group, the IL-4 group and the dexamethasone group. The expressions of COX-2, PDGF-A and PDGF-B in the lung tissue was detected by western blotting and RT-PCR.ResultsThe expressions of COX-2, PDGF-A and PDGF-B in the model group were increased significantly. Those expressions in the IL-4 and dexamethasone group were notably decreased.ConclusionIL-4 and dexamethasone could interfere in the establishment of COPD. The expressions of COX-2 and PDGF in the lung tissue of COPD were increased significantly and IL-4 and dexamethasone could decrease those expressions.