Effects of Connective Tissue Growth Factor and Collagen Type I Scleroderma

ObjectiveTo investigate the effects of connective tissue growth factor (CTGF) and collagen type I (COL-l) on the pathogenesis of scleroderma and explore the relationship between the level of COL-I and CTGF.Methods12 mice model of scleroderma was established by the injection of Bleomycin. The level of CTGF and COL-I were detected by immunohistochemical method. The relationship was analyzed between CTGF and COL-I level. As control group, 12 healthy mice were selected.ResultsThe levels of CTGF and COL-I in sclerotic models were higher than in normal controls (P < 0.05). It was found that there was a correlation between the level of CTGF and COL-I.ConclusionCTGF and COL-I played an important role in the hardening process of the skin lesions of the mice model, which may be involved in the pathogenesis of scleroderma.