کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3484325 1233739 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibacterial activities of methanol extracts from Alchornea cordifolia and four other Cameroonian plants against MDR phenotypes
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Antibacterial activities of methanol extracts from Alchornea cordifolia and four other Cameroonian plants against MDR phenotypes
چکیده انگلیسی

ObjectivesMultidrug-resistant (MDR) bacterial infections, especially those caused by Gram-negative phenotypes, have emerged as one of the major health concerns worldwide. In the present study, we investigated the antibacterial activity of methanol extracts from five Cameroonian medicinal plants (Alchornea cordifolia, Eremomastax speciosa, Laportea aestuans, Pennisetum purpureum and Spathodea campanulata) against 15 Gram-negative bacteria that included MDR phenotypes.MethodsThe broth microdilution method was used to determine the minimal inhibitory concentrations (MIC) and the minimal bactericidal concentrations (MBC) of all of the samples. Standard phytochemical methods were used for a preliminary phytochemical screening of the plant extracts.ResultsPhytochemical analysis showed the presence of polyphenols, tannins, triterpenes and sterols in all of the studied extracts. Other chemical classes of secondary metabolites were selectively identified. The best antibacterial activities (MICs ranges of 64–1024 μg/mL) obtained against the 15 tested bacteria were found in extracts of leaves (93.3%), bark (86.7%) and roots (80%) of A. cordifolia as well as extracts of L. aestuans (86.7%) and P. purpureum (66.7%). The lowest MIC value of 64 μg/mL was recorded for the A. cordifolia bark extract against Pseudomonas aeruginosa PA01.ConclusionsThe findings of this study provide deep insights into the possible use of the studied plants, especially A. cordifolia and L. aestuans, for the control of Gram-negative bacterial infections, especially against MDR species.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Taibah University Medical Sciences - Volume 11, Issue 2, April 2016, Pages 121–127
نویسندگان
, , , ,