Treatment of Uncontrolled Anterior Uveitis with 5- Fluorouracil: Case Series

A case series of six patients with uncontrolled anterior uveitis of different etiology were treated with subconjunctival injections of 5-Fluorouracil (5-FU 5.0 mg/0.1 ml with a total dose of 15–20 mg over 2–3 weeks. All patients showed complete remission of anterior uveitis and control of uveitic glaucoma for ≥ 9 months. 5-Fluorouracil might be an effective alternative to corticosteroids in controlling anterior uveitis. Patients at high risk of corticosteroids complications and those with uveitic glaucoma may benefit from this drug.