Effects of a filled fluoride-releasing enamel sealant versus fluoride varnish on the prevention of enamel demineralization under simulated oral conditions

BackgroundThe development of white spot lesions is a common complication of orthodontic treatment. The use of a patient-independent method to control white spot lesions is desirable. This randomized, controlled, in vitro study was conducted to compare the effect of the use of a filled, fluoride-releasing, light-cured enamel sealant (Pro-Seal) versus fluoride varnish on the prevention of demineralization of intact enamel surface.MethodsForty sound human premolar teeth were treated with either fluoride varnish or Pro-Seal sealant. Twenty sound human premolar teeth were used as controls. Specimens were subjected to thermocycling and brushing challenge protocols equivalent to 6 months and 1 year in oral environment. The teeth were then subjected to acid challenge. Prepared sections were examined under polarized light microscopy, and the depth of enamel demineralization was measured.ResultsThe fluoride varnish group showed significantly less lesion depth compared with the control group. The Pro-Seal group showed significantly less lesion depth compared with both the fluoride varnish group and the control group. Significantly deeper lesions were observed in specimens subjected to challenges equivalent to 1 year of oral environment compared with those subjected to challenges equivalent to 6 months of oral environment in the fluoride varnish group only.ConclusionApplication of either fluoride varnish or filled, fluoride-releasing, light-cured enamel sealant (Pro-Seal) was found to be efficacious in the prevention of enamel demineralization.