کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3486506 1596978 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and Cytotoxicity of 1,6,8,9-Substituted α-Carboline Derivatives
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis and Cytotoxicity of 1,6,8,9-Substituted α-Carboline Derivatives
چکیده انگلیسی

α-Carboline (pyrido[2,3-b]indole) was selected as the basic scaffold for development of antileukemic agents by structural modification. From the structure-activity study, it was found that sequential introduction of 6-acetyl and 9-substituted benzyl groups onto an α-Carboline scaffold resulted in 6-acetyl-9-(3,5-dimethoxybenzyl)-9H-pyrido[2,3-b]indole and 6-acetyl-9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indole with potent cytotoxicity against the HL-60 cell line. These two compounds will be used as new lead compounds for further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Kaohsiung Journal of Medical Sciences - Volume 26, Issue 11, November 2010, Pages 593-602