کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3491431 1234156 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
چکیده انگلیسی

SummaryAntiretroviral therapy for HIV infection needs lifelong access and strict adherence to regimens that are both expensive and associated with toxic effects. A curative intervention will be needed to fully stop the epidemic. The failure to eradicate HIV infection during long-term antiretroviral therapy shows the intrinsic stability of the viral genome in latently infected CD4T cells and other cells, and possibly a sustained low-level viral replication. Heterogeneity in latently infected cell populations and homoeostatic proliferation of infected cells might affect the dynamics of virus production and persistence. Despite potent antiretroviral therapy, chronic immune activation, inflammation, and immune dysfunction persist, and are likely to have important effects on the size and distribution of the viral reservoir. The inability of the immune system to recognise cells harbouring latent virus and to eliminate cells actively producing virus is the biggest challenge to finding a cure. We look at new approaches to unravelling the complex virus–host interactions that lead to persistent infection and latency, and discuss the rationale for combination of novel treatment strategies with available antiretroviral treatment options to cure HIV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 381, Issue 9883, 15–21 June 2013, Pages 2109–2117
نویسندگان
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