کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3799558 | 1244560 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Farmacogenética en oncologÃa
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Pharmacogenetics studies the relationship between genetic polymorphisms and individual responses to drugs. In recent years, there has been a great progress in our knowledge of the effects of drug-metabolizing enzymes and molecular target genetic polymorfisms on cancer chemotherapy. Pharmacogenetics focuses on the prediction of drug efficacy and toxicity based on a patient's genetic profile with routinely applicable genetic tests to select the most appropriate medication at optimal doses for each individual patient. Two years ago the FDA approved one genetic test to detect patients with increased risk of severe toxicity associated with irinotecan therapy. There have also been commercialized genetic chips to genotyping two cytochrome P450 enzymes at the same time. Prospectively, stratifying patients based on genotype may identify subpopulations likely to experience severe toxicity or to derive benefit from a particular treatment strategy, helping us move toward the ultimate goal of individualized therapy. In this review, we describe the clinical effects of polymorphisms that may influence cancer chemotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicina ClÃnica - Volume 131, Issue 5, July 2008, Pages 184-195
Journal: Medicina ClÃnica - Volume 131, Issue 5, July 2008, Pages 184-195
نویسندگان
Dominica Morán González, Silvia Jiménez Cabrera, Alfonso DomÃnguez-Gil Hurlé,