Vasculitis necrotizantes sistémicas. Vasculitis asociadas a ANCA

Systemic necrotizing vasculitides are a non homogeneous group of diseases defined by clinical symptoms of multivisceral involvement that are the consequence of severe inflammation of the arterial wall and histologically for the presence of fibrinoid necrosis. The polyarteritis nodosa (PAN) is a systemic vasculitides that affect the small-and medium-sized arteries. Antineutrophil cytoplasmatic antibody (ANCAs)-associated vasculitides include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and the allergic granulomatosis and angiitis or Churg Strauss syndrome (CSS) that affect essentially small-sized arteries. GPA and MPA vasculitides have a common renal involvement (pauci-immune crescentic glomerulonephritis) and share treatment and evolution. The SCS has a different presentation and prognosis compared with the other ANCAs.