Antiphospholipid syndrome

Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibody production can lead to a hypercoagulable state, pregnancy failure and/or a multitude of other systemic manifestations. In recent times, research into the antiphospholipid antibodies has increased our understanding of the pathogenic process and encouraged improved detection of antiphospholipid antibodies. However, the precise nature of the pathology of APS remains challenging, as does the management of this disorder. This review outlines the key features of APS, including the laboratory tests and their interpretation, and offers advice regarding the management of patients with APS both in the medical and obstetric settings.