کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3814935 1246045 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic associations with acute stress-related changes in eating in the absence of hunger
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Genetic associations with acute stress-related changes in eating in the absence of hunger
چکیده انگلیسی

BackgroundAcute psychological stress is associated with eating in the absence of hunger.ObjectiveTo investigate if BclI and FTO polymorphisms are associated with eating in the absence of hunger as a result of acute psychological stress.MethodsFTO (rs9939609) and BclI were genotyped in 98 subjects (BMI = 23.9 ± 3.3 kg/m2). In a randomized crossover design, the ‘eating in absence of hunger’ protocol was measured as a function of acute stress vs. a control task and of STAI (State Trait Anxiety Index) state scores.ResultsIn comparison with the FTO T allele, the A allele was associated with an increased feelings of hunger after food intake in the stress (11 ± 10 vs. 18 ± 15, p < 0.01) and control condition (12 ± 9 vs. 16 ± 12, p < 0.05), even though food intake was not different. For the first time, it was observed that in comparison to the BclI C/C genotype, the BclI G/G genotype was associated with higher STAI states scores at 0, 10, and 20 min after the stress condition (30.8 ± 6.4 vs. 36.3 ± 8.2; 28.3 ± 5.5 vs. 32.3 ± 7.5; 27.7 ± 6.1 vs. 31.2 ± 7.5, p < 0.05). Additionally, the BclI G/G genotype was associated with a larger difference in energy intake between the stress and control condition, in comparison with the BclI C/C genotype (136.6 ± 220.4 vs. 29.4 ± 176.3 kJ, p < 0.04).ConclusionIn concordance with previous studies, the FTO A allele is related to a lower feeling of hunger after a standardized meal. For the first time, the BclI G/G genotype is shown to be associated with increased sensitivity to psychological stress, and increased eating in the absence of hunger after stress.Practice implicationsInterventions to reduce body weight should consider the subjects’ genetic background.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Patient Education and Counseling - Volume 79, Issue 3, June 2010, Pages 367–371
نویسندگان
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