کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3817843 | 1246346 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Positron Emission Tomography Imaging and Hyperinsulinism
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Congenital hyperinsulinism is the most important cause of recurrent hypoglycemia in infancy and can be caused by two different histopathologic lesions, a focal or a diffuse form, based on different molecular abnormalities despite an indistinguishable clinical pattern. The differential diagnosis between the two forms is pivotal because focal disease is potentially curable by selective resection of the pancreatic focus, whereas diffuse forms require a subtotal pancreatectomy. Different conventional imaging modalities and invasive selective arterial calcium stimulation have been used to identify the two forms of the disease. Positron emission tomography imaging is a widely recognized noninvasive modality that is now standard of care for many oncologic processes based on its metabolic and functional capabilities. Based on the properties of L-dihydroxyphenylalanine as a precursor of catecholamines, this paper reviews the current and future potential applications that this technology has in accurately diagnosing the two main forms of congenital hyperinsulinism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PET Clinics - Volume 2, Issue 3, July 2007, Pages 377-383
Journal: PET Clinics - Volume 2, Issue 3, July 2007, Pages 377-383
نویسندگان
Miguel MD, PhD, Hongming MD, PhD, Stefano MD, Abass MD, PhD,