کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3828993 | 1247016 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SÃndrome antifosfolipÃdico obstétrico
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کلمات کلیدی
Antiphospholipid antibodies - آنتیبادی ضد فسفولیپیدAnticuerpos antifosfolipídicos - آنتیبادی ضد فسفولیپیدFetal loss - از دست دادن وزن جنینPregnancy - بارداریEmbarazo - بارداری یا حاملگیRecurrent miscarriages - سقط جنین مجددObstetric antiphospholipid syndrome - سندرم آنتی فسفولیپید زایمانPreeclampsia - پری اکلامپسی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Obstetric antiphospholipid syndrome is an acquired autoimmune disorder that is associated with various obstetric complications and, in the absence of prior history of thrombosis, with the presence of antiphospholipid antibodies directed against other phospholipids, proteins called cofactors or PL-cofactor complexes. Although the obstetric complications have been related to the procoagulant properties of antiphospholipid antibodies, pathological studies of human placenta have shown the proinflammatory capacity of antiphospholipid antibodies via the complement system and proinflammatory cytokines. There is no general agreement on which antiphospholipid antibodies profile (laboratory) confers the greatest obstetric risk, but the best candidates are categories I and IIa. Combined treatment with low doses of aspirin and heparin achieves good obstetric and maternal outcomes. In this study, we also review the therapeutic possibilities in refractory cases, although the likelihood of progressing to other autoimmune diseases is low. We briefly comment on incomplete obstetric antiphospholipid syndrome, also known as antiphospholipid antibody-mediated pregnancy morbidity syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista ClÃnica Española - Volume 216, Issue 3, April 2016, Pages 135-145
Journal: Revista ClÃnica Española - Volume 216, Issue 3, April 2016, Pages 135-145
نویسندگان
E. Esteve-Valverde, R. Ferrer-Oliveras, J. Alijotas-Reig,