کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3836529 1247545 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Newborn Jaundice Technologies: Unbound Bilirubin and Bilirubin Binding Capacity in Neonates
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Newborn Jaundice Technologies: Unbound Bilirubin and Bilirubin Binding Capacity in Neonates
چکیده انگلیسی

Neonatal jaundice (hyperbilirubinemia), which is extremely common in neonates, can be associated with neurotoxicity. A safe level of bilirubin has not been defined in either premature or term infants. Emerging evidence suggest that the level of unbound (or “free”) bilirubin has a better sensitivity and specificity than total serum bilirubin for bilirubin-induced neurotoxicity. Although recent studies suggest the usefulness of free bilirubin measurements in managing high-risk neonates, including premature infants, no widely available method exists to assay the serum free bilirubin concentration. To keep pace with the growing demand, in addition to reevaluation of old methods, several promising new methods are being developed for sensitive, accurate, and rapid measurement of free bilirubin and bilirubin binding capacity. These innovative methods need to be validated before adopting for clinical use. We provide an overview of some promising methods for free bilirubin and binding capacity measurements with the goal to enhance research in this area of active interest and apparent need.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Perinatology - Volume 35, Issue 3, June 2011, Pages 134–140
نویسندگان
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