Bone formation, remodelling and healing

Bone is one of the largest organs in the body receiving 5–10% of the cardiac output. Bone formation starts early in the first trimester in utero and throughout life, it is continuously resorbed and formed, a process known as remodelling. Bone (fracture) healing is a process closely linked with both formation and remodelling. This article explores the basic structure of bone and provides the current understanding of intramembranous and endochondral bone formation, remodelling and primary and secondary bone healing.