کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3841792 1248002 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum osteoprotegerin levels associated with the aortic augmentation index in renal transplant recipients
ترجمه فارسی عنوان
سطح استئوپروتدرین سرم با شاخص افزایشی آئورت در گیرندگان پیوند کلیه در ارتباط است
کلمات کلیدی
شاخص افزایشی آئورت؛ پيوند كليه؛ osteoprotegerin
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

ObjectivesArterial stiffness is recognized as an independent risk factor for cardiovascular morbidity and mortality. Recent studies found that osteoprotegerin (OPG) is associated with arterial stiffness and may reflect endothelial dysfunction. The aim of this study was to evaluate the relationship between fasting serum OPG levels and the aortic augmentation index (AIx) in renal transplant recipients.Materials and methodsFasting blood samples were obtained from 66 renal transplant recipients. The aortic AIx was measured using a validated tonometry system (SphygmoCor). Serum OPG levels were measured using a commercial enzyme-linked immunosorbent assay kit.ResultsUnivariate linear analysis of the aortic AIx in renal transplant recipients revealed that body fat mass (r = 0.377, p = 0.002), aortic diastolic blood pressure (DBP; r = 0.307, p = 0.020), triglycerides (r = 0.260, p = 0.035), and logarithmically transformed OPG (log-OPG, r = 0.402, p < 0.001) were positively correlated, whereas height (r = 0.361, p = 0.004) and body weight (r = 0.212, p = 0.041) were negatively correlated with the aortic AIx in renal transplant recipients. Multivariate forward stepwise linear regression analysis of the factors significantly associated with the aortic AIx showed that log-OPG (R2 = 0.213, p < 0.001), height (R2 = 0.081, p = 0.009), and aortic DBP (R2 = 0.058, p = 0.022) were independent predictors of the aortic AIx in renal transplant recipients.ConclusionThese results suggest that the serum fasting OPG level is associated with the aortic AIx in renal transplant recipients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tzu Chi Medical Journal - Volume 28, Issue 1, March 2016, Pages 20–23
نویسندگان
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