کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3846946 | 1248350 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bone Morphogenetic Protein 7 (BMP7): A Critical Role in Kidney Development and a Putative Modulator of Kidney Injury
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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چکیده انگلیسی
Bone morphogenetic protein 7 (BMP7), a member of the tumor growth factor β superfamily, appears to have a role in both kidney development and response to kidney injury. Signals through its pathways permit both epithelial differentiation during embryogenesis and preservation of normal kidney architecture after stress, leading to the hypothesis that BMP7 may exert its kidney-protective effects in adult animals by preventing or reversing epithelial-to-mesenchymal transformation. This review attempts to synthesize the data supporting those conclusions and suggest some future areas of research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Chronic Kidney Disease - Volume 15, Issue 3, July 2008, Pages 314-320
Journal: Advances in Chronic Kidney Disease - Volume 15, Issue 3, July 2008, Pages 314-320
نویسندگان
Patrick Archdeacon, Randal K. Detwiler,