کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3846959 1248351 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Focal Segmental Glomerulosclerosis and Chronic Kidney Disease in Pediatric Patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Focal Segmental Glomerulosclerosis and Chronic Kidney Disease in Pediatric Patients
چکیده انگلیسی
Focal segmental glomerulosclerosis (FSGS) is one of the most common forms of acquired glomerular disease leading to end-stage kidney disease. Its incidence is rising around the world. There is no proven therapy for those patients who do not respond to corticosteroids and it can recur in 20% to 25% of patients who receive a kidney transplant. The disease can be primary, or it can be secondary to various conditions including vesicoureteral reflux, obesity, medications, and infections. Recent advances have demonstrated the important role of genetic mutations in podocyte proteins as a cause of FSGS. There is an urgent need for randomized clinical trials to develop safe and effective therapy for FSGS that occurs in the native or transplanted kidney.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Chronic Kidney Disease - Volume 18, Issue 5, September 2011, Pages 332-338
نویسندگان
, , ,