کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3847204 | 1248369 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Renal Cystic Disease: The Role of the Primary Cilium/Centrosome Complex in Pathogenesis
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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![عکس صفحه اول مقاله: Renal Cystic Disease: The Role of the Primary Cilium/Centrosome Complex in Pathogenesis Renal Cystic Disease: The Role of the Primary Cilium/Centrosome Complex in Pathogenesis](/preview/png/3847204.png)
چکیده انگلیسی
Cystic diseases of the kidney are among the most frequent inherited disorders and constitute a significant cause of end-stage renal disease. Identification of the genes involved in these disorders and their protein products has provided key insights into the cellular processes that underlie cyst development and mediate disease progression. Of particular note, the proteins implicated in these disorders localize to the cilia/centrosome complex and have focused recent research on the role of this complex in the pathogenesis of renal cystic disease. Unraveling the spatial and functional relationship between these cystoproteins and the cilia/centrosome complex will undoubtedly provide a better understanding of the pathogenesis of cystic diseases and potentially offer windows for therapeutic intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Chronic Kidney Disease - Volume 13, Issue 2, April 2006, Pages 131-137
Journal: Advances in Chronic Kidney Disease - Volume 13, Issue 2, April 2006, Pages 131-137
نویسندگان
Brian J. Siroky, Lisa M. Guay-Woodford,