کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3850723 | 1598355 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytomegalovirus Glomerulopathy in a Kidney Allograft With Response to Oral Valganciclovir
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytomegalovirus Glomerulopathy in a Kidney Allograft With Response to Oral Valganciclovir Cytomegalovirus Glomerulopathy in a Kidney Allograft With Response to Oral Valganciclovir](/preview/png/3850723.png)
چکیده انگلیسی
Cytomegalovirus is an important viral pathogen in the kidney transplant population. Reports of direct cytopathic effects of cytomegalovirus in the kidney allograft are infrequent, with the majority of earlier reports highlighting tubulointerstitial involvement. We report a 58-year-old man who presented with an acute decrease in kidney allograft function 3 months posttransplantation. At presentation, both cytomegalovirus and polyomavirus blood polymerase chain reaction results were positive. Biopsy showed predominant glomerular endothelial involvement by cytomegalovirus with positive immunohistochemistry results. Polyomavirus was not detected in the biopsy specimen. He was treated with oral valganciclovir and a decrease in immunosuppression. He had a complete response, with clearance of viremia and return of allograft function to baseline. Recent reports of glomerular involvement may reflect changing practices in antiviral chemoprophylaxis and immunosuppressive regimen. Oral valganciclovir may have a role in the treatment of patients with mild viremia with tissue-invasive kidney disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 52, Issue 1, July 2008, Pages e1-e4
Journal: American Journal of Kidney Diseases - Volume 52, Issue 1, July 2008, Pages e1-e4
نویسندگان
Manish MD, Ramesh MD,