کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3851417 | 1598379 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rituximab Therapy for Epstein-Barr Virus-Related Chronic Hepatitis Following Living Donor Kidney Transplantation
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A patient who underwent living donor kidney transplantation was infected with Epstein-Barr virus (EBV) that resulted in persistent EBV infection and EBV-associated chronic hepatitis, determined by abnormally elevated anti-EBV antibody titers and high frequency of EBV-infected B lymphocytes. Despite decreases in immunosuppressant doses, persistent EBV infection and chronic hepatitis persisted for several years. Therapy using anti-CD20 monoclonal antibody (rituximab) virtually eliminated peripheral B lymphocytes and EBV-encoded small RNA 1 (EBER-1)-positive cells. Moreover, hepatic enzyme levels normalized and histological findings indicated marked improvement in hepatic inflammation. Although peripheral CD20+ B lymphocyte and EBER-1-positive cell levels began to increase 4 months after the end of therapy, the number of EBER-1-positive cells remained very low, and liver function test results remained within normal ranges. The present case illustrates the significance of early diagnosis, monitoring of viral load, and vigorous management of EBV-related disorders associated with organ transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 48, Issue 6, December 2006, Pages 986-989
Journal: American Journal of Kidney Diseases - Volume 48, Issue 6, December 2006, Pages 986-989
نویسندگان
Kazuhide MD, PhD, Masaki MD, PhD, Akiko MD, Tomoko MD, PhD, Yoshihito MD, PhD, Chihiro MS, Akihiro MD, PhD, Takeshi MD, PhD, Atsushi MD, PhD, Akira MD, PhD, Kazutaka MD, PhD, Hitoshi MD, PhD, Isao MD, PhD, Shoichi MD, PhD,