کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3852692 | 1598384 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Successful Treatment of a Patient With Severe Calcific Uremic Arteriolopathy (Calciphylaxis) by Etidronate Disodium
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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چکیده انگلیسی
A 59-year-old woman with a 10-year history of hemodialysis was admitted to our hospital for painful skin ulcers on her right thigh, right calf, and left upper arm. A whole-body plain computed tomographic scan showed diffuse calcification of the uterus and marked calcification of the mitral valve. Skin biopsy specimens from the left thigh showed calcium deposition in numerous small blood vessels in the dermis and fat, leading to a diagnosis of calcific uremic arteriolopathy (CUA). Despite antibiotic therapy and aggressive wound care for 2 months, the skin ulcers enlarged and the patient's general condition worsened. Surprisingly, oral administration of etidronate disodium (200 mg/d) strikingly improved the focal infection and decreased the size of the skin ulcers within several days. She was discharged from the hospital 2 months later, when epithelialization of the ulcers was almost complete. We report a case of CUA that was improved dramatically by treatment with etidronate. Etidronate therapy should be considered for refractory CUA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 48, Issue 1, July 2006, Pages 151-154
Journal: American Journal of Kidney Diseases - Volume 48, Issue 1, July 2006, Pages 151-154
نویسندگان
Naoki MD, PhD, Kenichiro MD, PhD, Taku MD, PhD, Masataka MD, PhD, Yukimasa MD, PhD, Hiroshi MD, PhD, Shuuko MD, Yoshihiro MD, PhD, Toshihiko MD, PhD, Masao MD, PhD, Kimio MD, PhD,