Effect of peritoneal dialysis on antioxidant defense system and oxidative stress

SummaryObjectiveIn this study we investigated the effect of peritoneal dialysis (PD) on some antioxidant markers and lipid peroxidation.MethodsThe levels of malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), vitamins A, E, and C, and total antioxidant capacity (TAC) were determined in 23 chronic ambulatory PD patients and 34 healthy controls.ResultsThe results showed MDA level in patients were not significantly different from those in controls. Erythrocyte SOD and GPX activities and vitamin C level were significantly decreased in the chronic ambulatory PD group (p < 0.0001), while the levels of TAC (p < 0.01), uric acid, and vitamins A (p < 0.0001) and E (p > 0.05) were enhanced with respect to the control group.ConclusionsThe findings suggest that despite slightly increased MDA level, patients on PD are exposed to oxidative stress, as evidenced by the decreased levels of SOD, GPx, and vitamin C. Depletion of these antioxidants may contribute to accelerated atherogenesis in these patients.

背景: 本研究旨在調查腹膜透析對抗氧化指標及脂質過氧化的影響。方法: 我們分別在23位腹膜透析患者(CAPD組)及34位健康人士(對照組)間，測量了malondialdehyde (MDA)、紅血球superoxide dismutase (SOD)與glutathione peroxidase (GPx)(酵素指標)、vitamin A、E、與C (非酵素指標)、及總抗氧化能力(TAC)水平。結果: 結果顯示，相比於對照組，CAPD組病人的MDA水平並無明顯差異，但具明顯較低的SOD與GPx活動及vitamin C數值(P <0.0001)。然而與對照組相比，CAPD組具較高的TAC (P < 0.01)、uric acid、及vitamin A (P<0.0001)與vitamin E (P>0.05)數值。結論: 本研究發現，即使具稍高的MDA數值，腹膜透析患者暴露於較高的氧化壓力中(反映於較低的SOD、GPx及vitamin C水平)。相關抗氧化物的損耗可能加速這些病人的動脈粥樣化進程。