Determinants of Plasma Adiponectin Levels in Nondiabetic Subjects With Moderate to Severe Chronic Kidney Disease

Gender, high-density lipoproteins, triglycerides, and high-sensitivity C-reactive protein are major determinants of adiponectin levels in nondiabetic stage III to IV CKD. Insulin resistance, body mass index, and body fat percentage were not associated with adiponectin levels. Plasma adiponectin levels are difficult to interpret in the setting of CKD because of multiple confounders that may influence the relationship between adiponectin, adiposity, and insulin resistance.