کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3859814 | 1598896 | 2015 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prosbiotate: A Multicenter, Prospective Analysis of Infectious Complications after Prostate Biopsy Prosbiotate: A Multicenter, Prospective Analysis of Infectious Complications after Prostate Biopsy](/preview/png/3859814.png)
PurposeProstate biopsy side effects have a role in the controversy over screening for prostate cancer. We measured the precise incidence of infection after prostate biopsy and determined risk factors.Materials and MethodsWe performed a prospective, multicenter study in France from April to June 2013. All prostate biopsies done during this period were included in study. A web based questionnaire was used to identify patient characteristics, biopsy methods and postoperative infectious episodes. External audit helped ensure data completeness. The primary outcome was the post-biopsy infection rate. We determined risk factors for infectious complications using univariate and multivariate analysis.ResultsThe study included 2,718 patients, of whom 6% reported receiving antibiotics in the previous 6 months and 7.4% had a history of prostatitis. Recommended antibiotic prophylaxis consisting of 2 fluoroquinolone tablets 2 hours before examination for prostate biopsy was noted in 78.3% of cases. Post-biopsy sepsis was found in 76 subjects (2.8%). On multivariate analysis predictors of post-biopsy sepsis were noncompliance with antibiotic prophylaxis guidelines (OR 2.3, 95% CI 1.4–3.9, p = 0.001), antibiotic treatment in the previous 6 months (OR 2.1, 95% CI 1.1–3.9, p = 0.015) and a history of prostatitis (OR 1.7, 95% CI 1.2–2.4, p = 0.002).ConclusionsIn this study the incidence of post-prostate biopsy sepsis was 2.8% and no deaths were reported. Risk factors identified on multivariate analysis were noncompliance with antibiotic prophylaxis according to guidelines, antibiotic treatment in the previous 6 months and a history of prostatitis.
Journal: The Journal of Urology - Volume 193, Issue 1, January 2015, Pages 145–150