کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3862931 1598944 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiological Changes in Transperitoneal Versus Retroperitoneal Laparoscopy in Children: A Prospective Analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Physiological Changes in Transperitoneal Versus Retroperitoneal Laparoscopy in Children: A Prospective Analysis
چکیده انگلیسی

PurposeThe choice of minimally invasive surgical approaches in pediatric urology is largely influenced by surgeon preference and experience. Little is known about the differences in physiological variables that might objectively influence the choice of surgical approach. We compared the cerebral and systemic hemodynamic effects of transperitoneal vs retroperitoneal CO2 insufflation in children.Materials and MethodsAfter receiving ethical review board approval and written parental consent 36 pediatric patients undergoing transperitoneal (18) or retroperitoneal (18) laparoscopic surgery were enrolled in this study. A standardized anesthetic technique of isoflurane 1 MAC and remifentanil 0.2 mcg/kg per minute was used. Measured parameters included end tidal CO2, middle cerebral artery blood flow velocity, heart rate and noninvasive mean arterial blood pressure. Transcranial Doppler ultrasound was used to measure middle cerebral artery blood flow velocity. Data were collected before, during and after CO2 insufflation to 12 mm Hg pneumoperitoneum at regular intervals, including every minute for 10 minutes and every 2 minutes thereafter. Within group analysis was done using repeated measures ANOVA. Nonlinear regression analysis was used to determine the best fit and the relationship of each variable with time with p <0.05 considered significant.ResultsPatient age and weight were comparable in the 2 groups. Transperitoneal CO2 insufflation resulted in a rapid parallel increase in middle cerebral artery blood flow velocity, mean arterial pressure and end tidal CO2 during the first 8 minutes of pneumoperitoneum (p <0.05). Despite a continued increase in end tidal CO2 thereafter middle cerebral artery blood flow velocity and mean arterial pressure attained a plateau within the first 8 minutes (p <0.05). In contrast, middle cerebral artery blood flow velocity and end tidal CO2 increased progressively throughout the retroperitoneal CO2 insufflation period (p <0.01).ConclusionsCerebral blood flow velocity and end tidal CO2 seem to increase progressively and gradually during retroperitoneal laparoscopy, in contrast to the more rapid increase and plateau effect during transperitoneal laparoscopy. Presumably the smaller absorptive surface in the retroperitoneal space explains this physiological difference.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Urology - Volume 186, Issue 4, Supplement, October 2011, Pages 1649–1652
نویسندگان
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