کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3865376 | 1598945 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Botulinum Toxin Type A in Patients With Parkinson's Disease and Refractory Overactive Bladder Botulinum Toxin Type A in Patients With Parkinson's Disease and Refractory Overactive Bladder](/preview/png/3865376.png)
PurposeIn this 6-month followup study we investigated the effect of intradetrusor injection of 100 U botulinum toxin type A in patients with Parkinson's disease and refractory detrusor overactivity.Materials and MethodsEight patients with Parkinson's disease and detrusor overactivity refractory to anticholinergics were injected with 100 U botulinum toxin type A. Daytime and nighttime urinary frequency, and urinary incontinence episodes were recorded. Patients also completed a standardized quality of life questionnaire on incontinence and a visual analog scale on the impact of bladder problems on daily life activities, and underwent urodynamic assessment, including pressure flow studies. Clinical and urodynamic assessment was performed before, and 1, 3 and 6 months after injection.ResultsIn all patients 100 U botulinum toxin type A induced decreased daytime and nighttime urinary frequency, a decreased number of urinary incontinence episodes, increased quality of life scores and, as shown by increased maximum cystometric capacity, improved urodynamic findings. In 2 patients with Parkinson's disease post-void residual urine volume developed.ConclusionsIntradetrusor injection of 100 U botulinum toxin type A induced clinical and urodynamic improvement in overactive bladder symptoms that lasted at least 6 months in patients with Parkinson's disease.
Journal: The Journal of Urology - Volume 186, Issue 3, September 2011, Pages 960–964