کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3872078 | 1598984 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidence of Partial Anti-Enuretic Response Related to Poor Pharmacodynamic Effects of Desmopressin Nasal Spray
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MNEDDAVPMonosymptomatic nocturnal enuresisICCs - ICC هاUrine osmolality - اسمولالیته ادرارInternational Children's Continence Society - جامعه مدنی بین المللی کودکانDesmopressin - دسموپسینdeamino arginine vasopressin - دیازینو آرژینین وازوپرسینNocturnal enuresis - زخم شبانهTreatment failure - شکست درمانPharmacokinetics - فارماکوکینتیکDrug resistance - مقاومت دارویی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pharmacodynamic tests reveal a suboptimal effect of desmopressin on urine concentration in a significant percentage of patients, which worsens when fluid is not restricted before desmopressin administration. Also the time to reach maximal antidiuretic effect and the duration of pharmacodynamic action show a wide range, requiring individualization of mode and time of administration. Our data demonstrate that a simple pharmacodynamic test as described may give important information on time of dosing, duration of action and influence of oral fluid intake, allowing individualization of therapy. Data also reveal that desmopressin should be administered at least 1 hour before bedtime, and that in case of therapy resistance a longer interval, up to 2 hours, might further reduce diuresis rate in the early night. Because of the documented prolonged action of desmopressin in some patients, increasing the dose without performing pharmacodynamic testing is no longer acceptable.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Urology - Volume 181, Issue 1, January 2009, Pages 302-309
Journal: The Journal of Urology - Volume 181, Issue 1, January 2009, Pages 302-309
نویسندگان
Ann De Guchtenaere, Ann Raes, Caroline Vande Walle, Piet Hoebeke, Erik Van Laecke, Raymond Donckerwolcke, Johan Vande Walle,