A solvent free method for preparation of β-amino alcohols by ring opening of epoxides with amines using MCM-22 as a catalyst

• Layered MCM-22 zeolite was utilized for the preparation of β-amino alcohols.
• Ring opening of epoxide using amine by MCM-22 catalyst in absence of solvent.
• The Catalyst exhibits excellent selectivity towards the mono alkylated product.
• Catalyst found to be promising for variety of epoxides and amines.
• Catalytic activity remains constant even after three repeated cycles.

β-amino alcohols were synthesized at room temperature employing microporous MCM-22 zeolite as catalyst in an eco-friendly manner without using solvent. The zeolite MCM-22 showed promising activity for the conversion of primary and secondary amines into β-amino alcohols under mild reaction conditions. The catalytic activity remains intact for three recycles.

Layered MCM-22 zeolite is identified as potential catalyst for the preparation of β-amino alcohols by ring opening of epoxides in the presence of amines under solvent free conditions.Figure optionsDownload high-quality image (120 K)Download as PowerPoint slide