EFFECTS OF BOTULINUM TOXIN B ON REFRACTORY DETRUSOR OVERACTIVITY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, CROSSOVER TRIAL

This double-blind, placebo controlled, crossover study provides evidence of the efficacy of botulinum toxin B in the treatment of overactive bladder. Autonomic side effects were observed in 4 patients. The short duration of action will presumably limit the use to patients who have experienced tachyphylaxis with botulinum toxin A.