Prostate Saturation Biopsy in the Reevaluation of Microfocal Prostate Cancer

This study is to our knowledge the first to describe the clinical use of prostate saturation biopsies for reevaluating potentially insignificant prostate cancer. Of patients with minimal disease on standard 10-core biopsy, results show that this technique may be helpful for distinguishing the 30% who probably have minimal disease based on negative repeat saturation biopsy from the 70% who almost certainly have a significant tumor, as characterized by multiple positive cores, with or without an increased Gleason score. The latter patients should be offered active therapy.