کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3884662 1249484 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of hemodialysis duration on the removal of uremic retention solutes
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Impact of hemodialysis duration on the removal of uremic retention solutes
چکیده انگلیسی

Several studies have stressed the importance of dialysis time in the removal of uremic retention solutes. To further investigate this, nine stable chronic hemodialysis patients were dialyzed for 4, 6, or 8 h processing the same total blood and dialysate volume by the Genius system and high-flux FX80 dialyzers. Inlet blood and outlet dialysate were analyzed for urea, creatinine, phosphorus, and β2-microglobulin at various times. Total solute removal, dialyzer extraction ratios, and total cleared volumes were significantly larger during prolonged dialysis for urea, creatinine, phosphorus, and β2-microglobulin. Reduction ratios increased progressively, except for phosphate and β2-microglobulin, where the ratios remained constant after 2 h. In contrast, no significant difference was found for the reduction ratios of all solutes and Kt/Vurea between the three different sessions. With longer dialyses, solutes are efficiently removed from the deeper compartments of the patient's body. Our study shows that care must be taken when using Kt/Vurea or reduction ratios as the only parameters to quantify dialysis adequacy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 73, Issue 6, 2 March 2008, Pages 765–770
نویسندگان
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