کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3891752 1250054 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A case of Fanconi syndrome accompanied by crystal depositions in tubular cells in a patient with multiple myeloma
ترجمه فارسی عنوان
یک مورد سندرم فانکنی همراه با ضایعات کریستال در سلول های لوله ای در یک بیمار مبتلا به مولتیپل میلوما
کلمات کلیدی
سندرم فانکونی، زنجیره کاپا ایمونوگلوبولین، میلوم چندگانه پروتئینوری
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
چکیده انگلیسی

Fanconi syndrome (FS) is a rare condition that is characterized by defects in the proximal tubular function. A 48-year-old woman was admitted for evaluation of proteinuria. The patient showed normal anion gap acidosis, normoglycemic glycosuria, hypophosphatemia, and hypouricemia. Thus, her condition was compatible with FS. The M peak was found behind the beta globulin region in urine protein electrophoresis. Upon bone marrow examination, we found that 24% of cells were CD138+ plasma cells with kappa restriction. From a kidney biopsy, we found crystalline inclusions within proximal tubular epithelial cells. Thereafter, she was diagnosed with FS accompanied by multiple myeloma. The patient received chemotherapy and autologous stem cell transplantation, and obtained very good partial hematologic response. However, proximal tubular dysfunction was persistent until 1 year after autologous stem cell transplantation. In short, we report a case of FS accompanied by multiple myeloma, demonstrating crystalline inclusion in proximal tubular cells on kidney biopsy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney Research and Clinical Practice - Volume 33, Issue 2, June 2014, Pages 112–115
نویسندگان
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