کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3896580 | 1250223 | 2013 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Potassium in Hypertension and Cardiovascular Disease Potassium in Hypertension and Cardiovascular Disease](/preview/png/3896580.png)
SummaryThe increased prevalence of hypertension and cardiovascular disease in industrialized societies undoubtedly is associated with the modern high-sodium/low-potassium diet. Extensive experimental and clinical data strongly link potassium intake to cardiovascular outcome. Most studies suggest that the sodium-to-potassium intake ratio is a better predictor of cardiovascular outcome than either nutrient individually. A high-sodium/low-potassium environment results in significant abnormalities in central hemodynamics, leading to potential target organ damage. Altered renal sodium handling, impaired endothelium-dependent vasodilatation, and increased oxidative stress are important mediators of this effect. It remains of paramount importance to reinforce consumption of a low-sodium/high-potassium diet as a critical strategy for prevention and treatment of hypertension and cardiovascular disease.
Journal: Seminars in Nephrology - Volume 33, Issue 3, May 2013, Pages 277–289