کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3896745 1250229 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drug Discovery for Diabetic Nephropathy: Trying the Leap From Mouse to Man
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Drug Discovery for Diabetic Nephropathy: Trying the Leap From Mouse to Man
چکیده انگلیسی

SummaryDiabetic nephropathy is the single major cause of kidney failure in the industrialized world and given the emerging global pandemic of diabetes mellitus, its prevalence is expected to only increase. Because of the lack of dynamic biomarkers that define the rate of kidney function loss, there are few proof-of-concept clinical trials for new therapeutics to treat diabetic nephropathy. A molecular understanding of the pathogenesis of diabetic nephropathy also is lacking. These deficiencies are magnified by the fact that most mouse models of diabetic nephropathy fail to show progressive kidney disease. Recently, some mouse models that showed requisite phenotypic changes of diabetic nephropathy have been identified. Validation of results obtained in these experimental models, and showing whether they accurately can predict clinical response to therapeutics in human diabetic nephropathy, must now be established.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Nephrology - Volume 32, Issue 5, September 2012, Pages 445–451
نویسندگان
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