کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3897296 1250249 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential Immunopathogenic Role of the Mucosa-Bone Marrow Axis in IgA Nephropathy: Insights From Animal Models
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Potential Immunopathogenic Role of the Mucosa-Bone Marrow Axis in IgA Nephropathy: Insights From Animal Models
چکیده انگلیسی
Impaired immune regulation along the mucosa-bone marrow axis has been postulated to play an important role in the pathogenesis of IgA nephropathy. Animal models have allowed us to study such changes in detail. Accumulating evidence from a number of animal models suggest that there is dysregulation of innate and cellular immunity in IgA nephropathy, resulting in changes to the mucosal immune system. These changes appear to be linked closely to a disruption of mucosal tolerance, resulting in the abnormal priming and dissemination of cells to sites such as the bone marrow where they are responsible for the synthesis of nephritogenic IgA. These findings suggest that future treatment strategies should focus on manipulating the priming and dissemination of these memory cells to prevent the appearance of nephritogenic IgA in the systemic compartment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Nephrology - Volume 28, Issue 1, January 2008, Pages 66-77
نویسندگان
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