Evaluation of Sperm Deoxyribonucleic Acid (DNA) Damage and Effects on Embryo Development Using a Mouse Cryptorchidism Model

This was an in vivo animal study to evaluate the effects of sperm DNA damage using a cryptorchidism model. Sperm DNA damage increased significantly over time after cryptorchidism. This model could be useful in investigating male factor infertility and evaluating the biologic effects of paternal DNA damage on fertilization and future embryonic development.