BRL37344, a β3-adrenergic Receptor Agonist, Decreases Nerve-evoked Contractions in Human Detrusor Smooth Muscle Isolated Strips: Role of BK Channels

This study supports the concept that β3-AR agonists inhibit nerve-evoked contractions in human DSM. We have further revealed that BK channels play a critical role in BRL37344-mediated relaxation of nerve-evoked contractions in human DSM. The study suggests that in addition to β3-ARs, BK channels may also represent promising pharmacologic targets in the treatment of urinary bladder dysfunction.